Test. b. Meprobamate. All of the following are general mechanisms of drug permeation Except (a) Aqueous diffusion (b) Aqueous hydrolysis (c) Lipid diffusion (d) Pinocytosis or endocytosis (e) Special carrier transport 2. Key: a Topic Specification: Skeletal Muscle Relaxants & Drug Acting on CNS (MCQ 10 – 12) Reference: Lippincott’s Pharmacology, 3rd Ed. (a) Pharmacologic antagonist (b) Partial agonist (c) Physiologic antagonist (d) Chemical antagonist (e) Noncompetitive antagonist 2. , 11 Which of the following terms best describes the antagonism of leukotriene’s bronchoconstrictor effect (mediated at leukotriene receptors) by terbutaline (acting a adrenoceptors) in a patient with asthma? It has an octanol coefficient of 10 B. tianaky. Question # 9 (Multiple Answer) Drug characteristics contributing to reliable transdermal drug absorption: A) molecular weight less than 1000 Medical Pharmacology Chapter 2: Drug Clearance: Liver Metabolism, Renal Excretion, Redistribution, Protein Binding; This is a self-grading exam. STUDY. Question # 3 (Multiple Choice) Hepatic flow-dependent drug elimination refers to: Answer: (B) rate-limiting step is drug delivery to hepatic elimination sites. The pulmonary epithelium as the primary site for metabolism. Match. Hard drugs are "non-metabolizable drugs" or drugs which are metabolized to biologically active metabolites. Multiple choice questions covering drug absorption, biotransformation, transport and excretion are presented. 2. Question # 14 (Multiple Answer) Phase II and reactions: Question # 15 (Multiple Choice) Factors affecting renal clearance of drugs: Question # 16 (Multiple Choice) Concerning drug-plasma protein binding: Question # 17 (Multiple Choice) Mixed function oxidases system is referred to as mediating: Question # 18 (Multiple Answer) Characteristics of drug-protein binding. , 12 Pharmacodynamics is BEST defined by which of the following? Question # 1 (Multiple Answer) Factors that could change intrinsic hepatic clearance include: Question # 2 (True/False) In rheumatoid arthritis patients, increased alpha1-acidic glycoprotein may be associated with increased lidocaine protein binding. , 13 Parenteral administration: a) Cannot be used with unconsciousness patients Pharm9: Drug Metabolism 10 Questions | By Stephengibbs | Last updated: Jul 30, 2011 | Total Attempts: 1438 Questions All questions 5 questions 6 questions 7 questions 8 questions 9 questions 10 questions PLAY. Correct answers are found through hyperlinks at the bottom of the page. c) Limiting metabolism. This is a self-grading exam. Also explore over 9 similar quizzes in this category. to increased metabolism of warfarin like drugs? 400 mls/min MCQ on Fatty Acid Synthesis and Breakdown (Lipid Metabolism) MCQ on … Pick out the parenteral route of medicinal agent administration: a) Rectal b) Oral c) Sublingual d) Inhalation 015. Question # 8 (Multiple Choice) Examples of "high-extraction" drugs -- related to hepatic drug clearance: Question # 9 (Multiple Choice) Pharmacogenetic effects: Question # 10 (Multiple Answer) Characteristics of drug conjugates (following conjugation reactions). Question # 3 (Multiple Choice) Hepatic flow-dependent drug elimination refers to: Question # 4 (Multiple Answer) Characteristic(s) of a drug whose action is terminate by redistribution include: Question # 5 (Multiple Choice) Cytochrome P450 induction (increased, amount of P450 enzyme protein) is often associated with: Question # 6 (Multiple Choice) Microsomal drug metabolizing enzymes are typically associated with: Question # 7 (Multiple Answer) Characteristics of drug-protein binding: Question # 8 (Multiple Choice) Examples of "high-extraction" drugs -- related to hepatic drug clearance: Question # 9 (Multiple Choice) Pharmacogenetic effects: Question # 10 (Multiple Answer) Characteristics of drug conjugates (following conjugation reactions). Try this amazing Pharmacology Drug Metabolism quiz which has been attempted 2663 times by avid quiz takers. Question # 19 (Multiple Answer) Factors affecting hepatic drug clearance: (A) drug delivery to liver elimination sites. , 10 We no longer publish the answers to the MCQs in the journal. , 4 Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. c) A drug is exposed more prominent liver metabolism d) A drug can be administrated in a variety of doses 014. , 6 Protein binding of a drug helps in. Question # 14 (Multiple Answer) Phase II and reactions: Question # 15 (Multiple Choice) Factors affecting renal clearance of drugs: Question # 16 (Multiple Choice) Concerning drug-plasma protein binding: Answer: (D) drug clearance is influenced by the extent of protein binding. , 3 Choose from 500 different sets of quiz drug metabolism medicinal chemistry flashcards on Quizlet. a) LD 50. b) LD 1. c) ED 50. d) ED 99. Acetanilide is a constituent of analgesic drugs. an increased rate of drug metabolism ? Distribution of drugs to specific tissues Lipid Metabolism: MCQs (Cholesterol, Triglycerides, and Other Lipids) Carbohydrate Metabolism: MCQ on Glycogen Synthesis and Breakdown. E) HMG-CoA. Terms in this set (204) Pharmacokinetics is: a) The study of biological and therapeutic effects of drugs ... metabolism of a drug usually decreases its water solubility synthesis of … c. Chlordiazepoxide. The metabolites of hard drugs are frequently toxic oxidation products. D) cytochrome P-450. Answers are entered by clicking the button corresponding to your selection. , 9 Question # 20 (Multiple Choice) Factors affecting renal drug secretion rates: Question # 21 (Multiple Choice) Concerning drug-plasma protein binding: Answer: (C) an example of a plasma protein important for drug binding is alpha1-acidic glycoprotein. increased sensitivity to drug therapy ? glycogen in liver and muscles. As drug concentration increases, metabolism shifts from first-order to zero-order kinetics. txt) or read online for free. It is detoxified to form p-Acetyl amino phenol. d) Thyroid hormone synthesis. B) alkaline phosphatase. … If hepatic blood flow is 1500 mls/min, the hepatic clearance is: A. Medicinal chemistry exam 1 - Free download as PDF File ( Medicinal chemistry 1 exam questions. , 20 b) Prolonging half life. 1 a lower oral dosage should be used A drug that is a weak organic acid (pK=3) would be least ionized in the: ? Question No : 1 The common key product in the inter mediary metabolism is, Question No : 2 Meeting point of all metabolic pathways is, Question No : 3 The process of conversion of harmful ammonia into urea within the liver cells during ornithine cycle is known as, Question No : 4 In mammals, carbohydrates are stored in the form of, Question No : 5 The breaking down of organic compounds and liberation of energy is, Question No : 6 In endotherms the main source of body heat is, Question No : 7 Enzymes, vitamins and hormones can be j classified under one catagory of biological chemicals because all of these, Competitive Exam India | Copyright @2017-2018 | About Us | Contact Us, Hosting partner DigitalOcean - Click here to get $10 joining bonus, DigitalOcean - Click here to get $10 joining bonus. d) … d) … d. Triazolam. a) Distribution. DRUGS OF ABUSE. A) drug metabolism by gastrointestinal flora B) drug hydrophilicity (opposite of lipophilicity) C) drug instability in gastric acid D) presence of food in the GI tract E) drug-drug interactions Question # 9 (Multiple Answer) Drug characteristics contributing to reliable transdermal drug absorption: A) molecular weight less than 1000 glucose in liver. , 17 Vancomycin e. Demeclocyline is a short acting tetracycline drug 9. All of the following are recognized adverse effects of isoniazid EXCEPT a. c) Aldosterone synthesis. , 5 Question # 11 (Multiple Choice) Termination of pharmacological action of thiopental occurs mainly by: Question # 12 (Multiple Answer) Concerning influence of age on drug responses:variation in response usually due to: Question # 13 (Multiple Choice) Reaction type associated with inactivation of succinylcholine, atracurium, and mivacurium. MCQ Kinetics, Dynamics. Question # 1 (Multiple Answer) Factors that could change intrinsic hepatic clearance include: Question # 2 (True/False) In rheumatoid arthritis patients, increased alpha1-acidic glycoprotein may be associated with increased lidocaine protein binding. , 14 Please use the Scantron Sheet provided. Lipid Metabolism: MCQs (Cholesterol, Triglycerides, and Other Lipids) 1) The cholesterol serves as the precursor for the following biosynthetic pathways EXCEPT. Purine and Pyrimidine Metabolism: MCQ. , 21. Question # 17 (Multiple Choice) Mixed function oxidases system is referred to as mediating: Question # 18 (Multiple Answer) Characteristics of drug-protein binding, (A) generally theextent of drug-protein binding parallels drug lipids liability, (D) sulfonamides may displace unconjugated bilirubin from albumin-binding sites (because neonatal bilirubin encephalopathy). There are 50 multiple choice questions worth 1. , 2 Write. Question # 5 (Multiple Choice) Cytochrome P450 induction (increased, amount of P450 enzyme protein) is often associated with: Question # 6 (Multiple Choice) Microsomal drug metabolizing enzymes are typically associated with: Question # 7 (Multiple Answer) Characteristics of drug-protein binding: (A) often parallels drug lipid solubility, (B) drug-plasma albumin binding tends to be relatively nonselective, (D) in rheumatoid arthritis patients, increased alpha1-acidic glycoprotein tends to promote increased lidocaine protein binding. First pass metabolism is not significant. a. Phenobarbital. Question # 4 (Multiple Answer) Characteristic(s) of a drug whose action is terminate by redistribution include: (C) eventually concentrates usually in adipose (fat) tissue. , 16 The plasma concentration after giving it is ... hepatic first pass metabolism. The enzyme system responsible for the metabolism of most drugs is: A) P-glycoprotein. a) Distribution. d) All three drugs have appropriate pharmacodynamic properties as they all achieve maximal physiological effects and have concentrations within the therapeutic window. Almost complete metabolism of morphine. 5 points each (75 Points). 1. The MCQs are in 10 point size for easier reading. A) drug metabolism by gastrointestinal flora B) drug hydrophilicity (opposite of lipophilicity) C) drug instability in gastric acid D) presence of food in the GI tract E) drug-drug interactions. Learn Pharmacology Multiple Choice Questions & Answers (MCQs), "Introduction to Pharmacology" quiz questions and answers for online Practice introduction to pharmacology MCQ: Study of drug properties, composition and medical applications is called, with choices botany Pharmacology mcq … A. Calcium channel antagonist B. Beta-blocker C. Benzodiazepines E. Slow injection of drug Spell. The functioning of the liver plays a significant role in the metabolism of drugs. C) Change this to ... GP01 [a] A drug is given at a dose of 50 mg/kg to a 70 kg man. Question # 19 (Multiple Answer) Factors affecting hepatic drug clearance: Question # 20 (Multiple Choice) Factors affecting renal drug secretion rates: Question # 21 (Multiple Choice) Concerning drug-plasma protein binding: Correct Answers Flashcards. , 19 The liver is the major site of drug transformation and elimination, and drugs administered by the oral route must pass through the liver prior to reaching systemic circulation. Hepatitis b. b) Steroid hormone synthesis. 15. Protein binding of a drug helps in. If pharmacologic effect is plotted versus drug concentration for most agents, the shape of the graph is: A) linear. mcq on pharmacology 1. , 8 Answers are entered by clicking the button corresponding to your selection. Gravity. Question # 11 (Multiple Choice) Termination of pharmacological action of thiopental occurs mainly by: Question # 12 (Multiple Answer) Concerning influence of age on drug responses:variation in response usually due to: Question # 13 (Multiple Choice) Reaction type associated with inactivation of succinylcholine, atracurium, and mivacurium. Used for the study of drug absorption & metabolism in human. Which … pdf), Text File (. Question 3 c) Limiting metabolism. e. Zolpidum. It has a pKa of 8.4 OP02 [Mar96] Which factor does NOT predispose to bradycardia with fentanyl in doses of 50 mcg/kg? Opioid MCQ OP01 [Mar96] With regards to pethidine’s physical properties: A. – increased phenytoin blood levels / toxicity e. CNS toxicity 10 acute rise in systemic concentrations of intravenous drugs parenteral... Isoniazid EXCEPT a on Quizlet used for the study of drug effectiveness in treating the disease & term. ) ED 50. d ) ED 50. d ) ED 99 different sets of quiz drug metabolism:! 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